Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests
نویسندگان
چکیده
منابع مشابه
Normal thrombin generation in neonates in spite of prolonged conventional coagulation tests.
Conventional coagulation tests might be inadequate to explore mechanisms regulating thrombin generation in neonates, because they do not allow full activation of the reduced levels of protein C. Therefore, they do not reflect the action of pro- and anti-coagulants as does the endogenous thrombin potential assessed in the presence of thrombomodulin. Endogenous thrombin potential measured without...
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BACKGROUND Liver disease is accompanied by profound hemostatic disturbances. We investigated the influences of pro- and anticoagulation factors on global coagulation tests including prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin generation assay (TGA) in cirrhosis. We also investigated whether cirrhotic patients exhibit hypo- or hypercoagulability using the TG...
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We have investigated the influence of alterations in plasma coagulation factor levels between 50% and 150% of their mean values for prothrombin, factor X, factor XI, factor IX, factor VII, factor VIII, factor V, protein C, protein S, antithrombin III (AT-III), and tissue factor pathway inhibitor (TFPI) as well as combinations of extremes, eg, 50% anticoagulants and 150% procoagulants or 50% pro...
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Test for the evaluation of the overall coagulation potential in plasma. Given the central role of thrombin in blood clotting, the tendency of a plasma sample to generate thrombin might contain useful information about thrombotic or haemorrhagic risk. In this presentation I will talk about the thrombin generation (TG) assay by the Calibrated Automated Thrombogram (CAT), developed in Maastricht b...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2005
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.20569